Nosocomial Drug-Resistant Bacteremia in 2 Cohorts with Cryptococcal Meningitis, Africa

Technical Appendix Table 1. Demographic data for persons with cryptococcal meningitis by nosocomial bacteremia status, Kampala, Uganda and Cape Town, South Africa* Study site, baseline demographics Without bacteremia With bacteremia Univariate p value Kampala, Uganda No. 94 21 NA Age, y 35 (30–40) 36 (31–43) 0.37 Male sex 43 (46) 15 (71) 0.052 CD4 count, cells/μL 16 (7–70) 17 (6–60) 0.71 HIV viral load, log10 copies/mL 5.4 (5.2–5.7) 5.6 (5.5–5.8) 0.024 Leukocytes x 10/L 3.6 (2.6–4.9) 4.2 (3.1–6.0) 0.27 Thrombophlebitis 14 (47)† 13 (62) 0.39 Deaths at 10 wk 34 (36) 11 (52) 0.22 Cape Town, South Africa No. 65 7 NA Age, y 36 (28–43) 34 (23–42) 0.66 Male sex 35 (54) 5 (71) 0.45 CD4 count, cells/μL 61 (16–98) 14 (11–43) 0.028 HIV viral load, log10 copies/mL 5.1 (4.6–5.7) 5.4 (4.8–5.5) 0.80 Leukocytes x 10/L 5.0 (3.4–6.2) 3.5 (2.2–5.0) 0.11 Thrombophlebitis 20 (50)† 6 (85) 0.11 Deaths at 10 wk 22 (35)‡ 2 (29) 0.99 *Values are median (interquartile range) or no. (%) unless otherwise indicated. NA, not applicable. p values were calculated for continuous variables by using the Mann-Whitney U and for categorical variables by using the Fisher exact test. †Detailed chart extraction was performed for thrombophlebitis on 30 persons without bacteremia in Kampala (n = 30) and on 40 persons in in Cape Town matched within 1 mo of diagnosis of a case-patient with bacteremia. ‡Two persons were lost to follow-up.